Cognitive function, serum BDNF levels and BDNF gene Val66Met polymorphism in amnestic mild cognitive impairment / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 321-325, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-814076
ABSTRACT
OBJECTIVE@#To investigate the relationship between serum brain-derived neurotrophic factor, concentrations and BDNF gene Val66Met polymorphism and amnestic mild cognitive impairment (aMCI), and neuropsychological characteristics.@*METHODS@#Ninety-nine aMCI patients and 99 matched normal controls were recruited for the study. Multi-dimension neuropsychologic tests were used to extensively assess the cognitive function, an enzyme-linked immunosorbent assay was applied to measure serum BDNF concentrations, and polymerase chain reaction-restriction fragment length polymorphism was used to analyse BDNF gene Val66Met polymorphism in the subjects.@*RESULTS@#The scores of neuropsychologic tests in aMCI patients were significantly lower than those in the normal controls (all P0.05).@*CONCLUSION@#aMCI is characterized by episodic memory impairment. Decreased BDNF concentrations may play a role in the pathophysiology of aMCI, and BDNF gene Val66Met polymorphism may not be an important genetic factor in susceptibility to aMCI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Valine
/
Blood
/
Cognition Disorders
/
Brain-Derived Neurotrophic Factor
/
Alzheimer Disease
/
Genetics
/
Amnesia
/
Methionine
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS