Effect of 5-HT and postsynaptic 5-HT1 A on the mood and recogniztion of the repeated restraint stress in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 305-311, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-814079
ABSTRACT
OBJECTIVE@#To explore the role of 5-HT and postsynaptic 5-HT1A receptors in the stress adaptation.@*METHODS@#p-PCA was used to deplete the 5-HT in rats. The 5-HT1A agonist 8-OH-DPAT and antagonist WAY100635 were used to determine the effect of postsynaptic 5-HT1A receptors on the ratso behaviors in the Elevated Plus-Maze test, the Forced Swimming test, and the Morris Water Maze test.@*RESULTS@#Compared with the intact rats, the 5-HT depleted rats showed more seriously anxious behaviors in the Elevated Plus-Maze test and more obvious learned helplessness in the Forced Swimming test. After having been stressed the 5-HT depleted rats showed significantly impaired learning and memory compared with the intact rats according to Morris Water Maze test. Activation of postsynaptic 5-HT1A receptors by 8-OH-DPAT in the 5-HT depleted rats or the 5-HT depleted stress rats significantly decreased the symptoms of anxiety and learned helplessness behaviors which were prevented by the treatment of WAY100635. The 8-OH-DPAT and WAY100635 had no obvious effect on the 5-HT depletion or 5-HT depleted stress rats in the Morris Water Maze test.@*CONCLUSION@#Deficiency of 5-HT in rats may suppress its ability to stress adaptation. Activation of post-synaptic 5-HT1A receptors can attenuate the anxiety and depressive behavior symptoms, and facilitate rats to adapt stress.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Psychology
/
Stress, Psychological
/
Synaptosomes
/
Restraint, Physical
/
Random Allocation
/
Serotonin
/
Chemistry
/
Rats, Sprague-Dawley
/
Affect
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Type:
Article
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