Biochemical markers of age-related changes in bones turnover and bone mineral density in healthy Chinese men / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 53-56, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-814124
ABSTRACT
OBJECTIVE@#To determine the relationship between bone alkaline phosphatase (BAP) and cross-linked N-telopeptides of type I collegen(NTX) and bone mineral density in healthy men aged 20-80.@*METHODS@#BAP and NTX of 389 healthy men were measured by ELISA. BMD at the lumbar spine and the hip as measured by dual energy X-ray absorptiometry. The correlation of bone biochemical markers with age and BMD fit 10 regression models.@*RESULTS@#BAP and NTX negatively correlated with age. The cubic regression model was better with age-related changes of bone biochemical markers as compared with the other regression models and the coefficients of determination of fitting curve were 0.013-0.029 (P< 0.05). The value of bone biochemical markers as the highest during 20-29 age groups, then they decreased to a nadir level in the 50-59 years age. After 60 years, bone formation markers remained stable; however resorption marker increased slightly. After adjustment for age, weight, height, BMI, and smoking, bone biochemical markers were negatively correlated with most sites of BMD.@*CONCLUSION@#BAP and NTX may be relatively sensitive and specific markers to evaluate age-related changes of bone turnover. It may benefit the prevention of osteoporosis by monitoring the level of BAP and NTX.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Peptides
/
Bone and Bones
/
Biomarkers
/
Bone Density
/
Age Factors
/
Collagen Type I
/
Alkaline Phosphatase
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Type:
Article
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