Expression and significance of human beta-defensin in recurrent nasal polyps / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1119-1122, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-814141
ABSTRACT
OBJECTIVE@#To observe the expression of human beta-defensin-1 (hBD-1) and human beta-defensin-2 (hBD-2) in recurrent nasal polyps, and to investigate the role of beta-defensin in the recurrent nasal polyps.@*METHODS@#Tissues of nasal polyps was obtained from 10 patients with nasal polyps undergoing endoscopic sinus surgery, recurrent nasal polyps from 10 patients 6 months after surgery, nasal mucosa from 10 recovered patients with nasal polyps postoperatively and,10 control subjects. hBD-1 mRNA and hBD-2 mRNA levels of tissue specimens in all groups were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).@*RESULTS@#There was no significant difference in hBD-1 mRNA level between the 4 groups (P>0.05). Expression of hBD-2 mRNA was detected in patients with nasal polyps and recurrent nasal polyps, but rare in the recovered patients and the control subjects.@*CONCLUSION@#hBD-1 is a constitutive expression and hBD-2 is an induced expression. beta-Defensin may play an important role in forming the nasal polyps.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
RNA, Messenger
/
Case-Control Studies
/
Nasal Polyps
/
Reverse Transcriptase Polymerase Chain Reaction
/
Beta-Defensins
/
Genetics
/
Metabolism
/
Nasal Mucosa
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Type:
Article
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