Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 926-930, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-814174
ABSTRACT
OBJECTIVE@#To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways.@*METHODS@#Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n=20) and a treatment group(n=60) which were further evenly divided into Group A (transplanted through the vena caudalis), Group B (transplanted through the ventriculus cerebri lateralis), and Group C (transplanted through the injured brain area). Each group was transplanted with amniotic-derived esenchymal stem cells, and their therapeutic efficacy would be evaluated through the neurological severity score (NSS).@*RESULTS@#Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P0.05).@*CONCLUSION@#Transplanting the amniotic-derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Therapeutics
/
Brain Injuries
/
Random Allocation
/
Rats, Wistar
/
Cell Biology
/
Mesenchymal Stem Cell Transplantation
/
Mesenchymal Stem Cells
/
Amnion
/
Methods
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Type:
Article
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