Automated synthesis of 2-(18)F-fluoro-2-deoxy-D-glucose by on-column hydrolysis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1151-1156, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-814179
ABSTRACT
OBJECTIVE@#To study automated synthesis of 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) via on-column hydrolysis.@*METHODS@#Automated synthesis of (18)F-FDG was performed by the on-column hydrolysis procedure in TRACERlab FXF-N synthesizer. (18)F-FDG injection was obtained via nucleophilic fluorination of 1, 3, 4, 6-tetra-O-acetyl-2-O-trifluoromethanesulfony-beta-D-mannopyranose as the precursor molecule with (18)F-fluoride, hydrolysis of the (18)F-labeled intermediate on SEP-PAK C18 cartridges with 2 mol/L NaOH solution, and purification and neutralization with SEP-PAK cartridges.@*RESULTS@#The uncorrected radiochemical yield of (18)F-FDG was more than 60% within the total synthesis time shorter than 20 min. The radiochemical purity of (18)F-FDG was above 99%.@*CONCLUSION@#On-column hydrolysis is simple and practical for the automated synthesis of (18)F-FDG. (18)F-FDG injection produced by this procedure can be used in clinical PET imaging.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Automation
/
Diagnostic Imaging
/
Radiography
/
Radiopharmaceuticals
/
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
/
Hydrolysis
/
Kidney Neoplasms
/
Liver Neoplasms
/
Methods
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2009
Type:
Article
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