Expression of FGF-2 and osteopontin in non-small cell lung cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1114-1119, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-814186
ABSTRACT
OBJECTIVE@#To investigate the expression of fibroblast growth factor-2 (FGF-2) and osteopontin (OPN) in non-small cell lung cancer (NSCLC) tissues and analyze the correlation between FGF-2 and OPN.@*METHODS@#Immunohistochemical SP method was used to detect the expression of FGF-2 and OPN in 76 patients with NSCLC and 15 normal lung tissues. The effect of FGF-2 on OPN expression at mRNA and protein level in A549 cell was examined by RT-PCR and Western blot.@*RESULTS@#The positive expression of FGF-2 (65.8%) and OPN (60.5%) in the NSCLC tissues was significantly higher than that in the normal lung tissues (13.3% and 0, respectively ) (P0.05).A positive correlation was found between the expression of FGF-2 and OPN in NSCLC (r=0.552,P<0.01). The expression of OPN protein and mRNA was up-regulated by FGF-2 in A549 cells.@*CONCLUSION@#The overexpression of FGF-2 and OPN is related to the metastasis and invasion of NSCLC.FGF-2 may promote the metastasis and invasion of NSCLC depending on the upregulation of OPN expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Fibroblast Growth Factor 2
/
Carcinoma, Non-Small-Cell Lung
/
Osteopontin
/
Genetics
/
Lung Neoplasms
/
Metabolism
/
Neoplasm Metastasis
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2009
Type:
Article
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