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Isoflurane preconditioning decreases the plasma concentration of matrix metalloproteinase-9 and protects myocardium against cardiopulmonary bypass in cardiac valve replacement / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 158-164, 2009.
Article in Chinese | WPRIM | ID: wpr-814234
ABSTRACT
OBJECTIVE@#To explore the effect of isoflurane preconditioning on the plasma concentration of matrix metalloproteinase (MMP)-9 and myocardial ultramicrostructure in patients undergoing cardiac valve replacement.@*METHODS@#Thirty patients undergoing elective cardiac valve replacement with cardiopulmonary bypass (CPB) were randomly assigned to a control group (ný15) and an isoflurane group (ný15). In the isoflurane group, isoflurane of 1.0 minimum alveolar concentration end-tidal( 1.1% approximately 1.2%) was administered for 30 min followed by a 15 min washout period before the CPB. The control group did not inhale isofurane, and there was no difference in the other drugs in the 2 groups. Blood samples for MMP-9 were obtained before incision(T(0)) and at 30 min (T(1)),6 h (T(2)),12 h (T(3)), and 24 h (T(4)) after the reperfusion. Right atrial biopsies were collected before and after the CPB to observe the myocardial ultramicrostructure.@*RESULTS@#Compared with T(0), the mean MMP-9 level significantly increased at T(1), T(2) and T(3) in the control group(P<0.01), while the MMP-9 level only at T(1) significantly increased in the isoflurane group (P<0.01). The mean MMP-9 level was significantly reduced in the isoflurane group at T(2) compared with each time point in the control group. The difference in MMP-9 levels between T(1), T(2), T(3) and T(0) was significantly lower in the isoflurane group than that in the control group (P<0.01). The ultramicrostructure injury of myocardium under electron microscope in the control group was worse than that in the isoflurane group.@*CONCLUSION@#The plasma concentration of MMP-9 is inhibited by isoflurane preconditioning in patients undergoing cardiac valve replacement after CPB, which might be part of its protective mechanism against myocardium injury after CPB.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Cardiopulmonary Bypass / Cardiotonic Agents / Ischemic Preconditioning, Myocardial / Heart Valve Prosthesis Implantation / Matrix Metalloproteinase 9 / Therapeutic Uses / Isoflurane / Methods / Myocardium Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Cardiopulmonary Bypass / Cardiotonic Agents / Ischemic Preconditioning, Myocardial / Heart Valve Prosthesis Implantation / Matrix Metalloproteinase 9 / Therapeutic Uses / Isoflurane / Methods / Myocardium Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2009 Type: Article