Effect of yizhi jiannao granules on the expression of Pin1 and HMGB1 mRNA in the hippocampus of SAMP8 mice / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 63-66, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-814250
ABSTRACT
OBJECTIVE@#To investigate the effect of yizhi jiannao granule concentration fluid (YCF) on the expression of peptidyl-prolyl-cis-trans isomerase A (Pin1) and high mobility group box 1 (HMGB1) mRNA in the hippocampus of senescence accelerated mice Senile-Prone8(SAMP8).@*METHODS@#Six-month old SAMP8 mice were randomly divided into a YCF group and a model group. Six-month old SAMP8 mice were served as a normal control group. The YCF group was ravaged, while the model group and the normal control group were gavaged with double-distilled water for 8 weeks. The hippocampus was taken out for examination. The expression of Pin1 and HMGB1 mRNA was measured by RT-PCR.@*RESULTS@#In the YCF group, the level of Pin1 mRNA increased, and the level of HMGB1 mRNA decreased compared with that of the model group.@*CONCLUSION@#Yizhi jiannao granules can prevent Alzheimer's disease by increasing the Pin1 level and decreasing the HMGB1 level.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Aging
/
RNA, Messenger
/
Drugs, Chinese Herbal
/
Peptidylprolyl Isomerase
/
HMGB1 Protein
/
Alzheimer Disease
/
NIMA-Interacting Peptidylprolyl Isomerase
/
Genetics
/
Hippocampus
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2009
Type:
Article
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