Clinicopathologic features and diagnosis of 18 patients with angioimmunoblastic T-cell lymphoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 523-526, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-814293
ABSTRACT
OBJECTIVE@#To explore the clinical and pathologic features of angioimmunoblastic T-cell lymphoma(AITL) and provide evidence for diagnosis.@*METHODS@#Eighteen AITL patients (9 males and 9 females aged from 14 to 70 years) were retrospectively analyzed in Xiangya Hospital of Central South University from July 2002 to September 2007.@*RESULTS@#Characteristic features at the presentation of AITL included generalized lymphadenopathy, fever, splenomegaly, and skin rashes with polyclonal hyper-gammaglobulinemia and other hematological abnormalities (such as Coombs-positive hemolytic anemia), which often involved the bone marrow and had well-described histologic features. The positive rate for CXCL13 was 93.3%.@*CONCLUSION@#Repeated lymphadenbiopsy is helpful for AITL diagnosis. Routine histological and immunohistochemical examinations (especially including CXCL13) play significant role in the diagnosis and differential diagnosis of AITL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Retrospective Studies
/
Lymphoma, T-Cell, Peripheral
/
Diagnosis
/
Chemokine CXCL13
/
Immunoblastic Lymphadenopathy
/
Metabolism
Type of study:
Diagnostic study
/
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2009
Type:
Article
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