Mutation analysis of neural cell adhesion molecules in human astrocytoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 510-514, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-814295
ABSTRACT
OBJECTIVE@#To identify the function of neural cell adhesion molecule (NCAM) mutation in the genesis of human glioma.@*METHODS@#Mutations were found through polymerase chain reaction-single strand conformation polymorphism, and then the changed DNA fragments were purified and multiplied and sent to Shanghai for sequencing. Blast and ORF finder were used to find out the amino changes in NCAM.@*RESULTS@#An A-C transversion was found at position 1 126 in NCAM's 7 exon in a patient with glioblastoma from 43 astrocytoma.@*CONCLUSION@#Structural change in the protein caused by point mutation may be the reason for tumorigenesis of astrocytoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Astrocytoma
/
Brain Neoplasms
/
DNA Mutational Analysis
/
Molecular Sequence Data
/
Base Sequence
/
Point Mutation
/
CD56 Antigen
/
Genetics
/
Metabolism
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2009
Type:
Article
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