Association of serum follicle stimulating hormone with osteoprotegerin, leptin, TGF-β1, and TGF-β2 in women / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To determine the relation between follicle-stimulating hormone (FSH) level and bone metabolism-related cytokines in women.@*METHODS@#A cross-sectional study of 703 healthy Chinese women, aged 20-80 years, was conducted. Serum FSH, osteoprotegerin (OPG), leptin, transforming growth factor-beta 1 (TGF-β1), and transforming growth factor-beta 2 (TGF-β2) were detected.@*RESULTS@#Serum FSH was positively correlated with OPG (r=0.447, P<0.01) and TGF-β2 (r=0.344, P<0.01), and negatively correlated with TGF-β1 (r=-0.374, P<0.01). After adjustment of age, a negative correlation was found between FSH and leptin (r=-0.265, P<0.01). The multiple linear stepwise regression analysis showed that serum FSH was a negative determinant factor of TGF-β1, and 22.6% changes in TGF-β1 was determined by FSH. FSH was, however, a positive determinant factor of OPG and TGF-β2, and 9.9% and 1.1% of the effect on OPG and TGF-β2 was performed by FSH, respectively. Serum FSH almost had no effect on leptin.@*CONCLUSION@#Serum FSH level in adult women is related to bone metabolism-related cytokines, such as TGF-β1, OPG, and TGF-β2.