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Effect of pregnancy-associated plasma protein-A on the function of endothelial cells / 中南大学学报(医学版)
Article in Chinese | WPRIM | ID: wpr-814335
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To determine the effect of pregnancy-associated plasma protein A (PAPP-A) on the function of vascular endothelial cells (VEC).@*METHODS@#Human umbilical vein endothelial cell (HUVEC) line, derived from human umbilical vein, was cultured in vitro with PAPP-A at 0, 50, 100, and 200 ng/mL for 0, 12, 24, and 48 hours, respectively. Nitric oxide (NO) levels and endothlin-1 (ET-1) levels were determined by spectrophotometer and immunehistory.@*RESULTS@#The NO levels of HUVECs in the PAPP-A groups were significantly lower than those in the control group (P<0.05). The ET-1 levels of HUVECs in the PAPP-A groups were significantly higher than those in the control group (P<0.05). The changes were all dose-dependent.@*CONCLUSION@#PAPP-A may affect the function of vascular endothelial cells by reducing the secretion of NO and increasing the level of ET-1.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Pregnancy-Associated Plasma Protein-A / Umbilical Veins / Female / Humans / Cell Line / Endothelin-1 / Cell Biology / Endothelial Cells Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Pregnancy-Associated Plasma Protein-A / Umbilical Veins / Female / Humans / Cell Line / Endothelin-1 / Cell Biology / Endothelial Cells Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2010 Type: Article