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Correlation between multi-slice spiral CT pulmonary perfusion imaging and cavity of microvessel in lung cancer / 中南大学学报(医学版)
Zhongnan Daxue xuebao. Yixue ban ; (12): 1242-1247, 2010.
Article in Zh | WPRIM | ID: wpr-814338
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To investigate the relation between multi-slice spiral CT pulmonary perfusion imaging and the cavity of microvessel in lung cancer.@*METHODS@#Altogether 36 patients with malignant nodules who underwent multi-slice spiral CT perfusion scan were examined.The perfusion parameters were collected and compared with the microvessel density (MVD), the incomplete lumen MVD, and the differentiation of non-small cell lung cancer (NSCLC). The patients were divided into a hyper-perfusion group and a hypo-perfusion group by the value of perfusion parameters. The maturity of microvessel and the degree of differentiation in NSCLC between the 2 groups was analyzed.@*RESULTS@#Blood flow (BF), blood volume (BV), and peak enhancement image(PEI) of the malignant nodules were (39.7±11.5) mL/(100 mg.min), (8.6±3.8)mL/100 g, and (20.1±8.6)HU, respectively. There was a positive correlation between PEI and MVD(r=0.645,P<0.01), and a negative correlation between BF and MVD(r=-0.280,P=0.048). There were negative correlations of BF, BV, PEI with the incomplete lumen MVD (P<0.05). BF had the highest correlation coefficient(r=-0.882,P<0.01).The incomplete lumen MVD of the hyper-perfusion group was significantly lower than that of hypo-perfusion group (P<0.05),but there was no significant difference in MVD between the 2 groups. There were negative correlations of BF, BV,PEI with the degree of differentiation (P<0.05). BF had the highest correlation coefficient(r=-0.751,P<0.01).@*CONCLUSION@#Multi-slice spiral CT pulmonary perfusion imaging is helpful to evaluate the degree of differentiation and status of angiogenesis in lung cancer, and its basis is the cavity of microvessel.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pathology / Capillaries / Diagnostic Imaging / Solitary Pulmonary Nodule / Carcinoma, Non-Small-Cell Lung / Tomography, Spiral Computed / Diagnosis, Differential / Lung Neoplasms / Methods / Neovascularization, Pathologic Type of study: Diagnostic_studies Limits: Female / Humans / Male Language: Zh Journal: Zhongnan Daxue xuebao. Yixue ban Year: 2010 Type: Article
Full text: 1 Index: WPRIM Main subject: Pathology / Capillaries / Diagnostic Imaging / Solitary Pulmonary Nodule / Carcinoma, Non-Small-Cell Lung / Tomography, Spiral Computed / Diagnosis, Differential / Lung Neoplasms / Methods / Neovascularization, Pathologic Type of study: Diagnostic_studies Limits: Female / Humans / Male Language: Zh Journal: Zhongnan Daxue xuebao. Yixue ban Year: 2010 Type: Article