Association between polymorphism of rs3212855 and rs5515 of KLK1 gene with cerebral hemorrhage in Changsha Han population / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To explore the association between single nucleotide polymorphism (SNPs) of KLK1 gene and cerebral hemorrhage in Changsha Han population.@*METHODS@#We enrolled 273 patients with cerebral hemorrhage and 140 normal people. The SNPs (including rs3212855 and rs5515) of KLK1 gene were analyzed by Snapshot method and direct sequencing.@*RESULTS@#We found rs5515 was not a polymorphic site in Changsha Han population. Genotype and allele frequency in rs3212855 were not different between patients with cerebral hemorrhage and the controls (P>0.05). The blood pressure level was not different between the genotype subgroups.@*CONCLUSION@#Neither rs5515 nor rs3212855 is associated with cerebral hemorrhage.