Research progress in aldose reductase / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 395-400, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-814433
ABSTRACT
Aldose reductase is a member of aldehyde-keto reductase superfamily widely existing in the kidney, adrenal gland, lens, retina, nerve, heart, placenta, brain, skeletal muscle, testis, blood vessels, lung, liver, et al. It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various aldehydes and ketones to the corresponding alcohol. It is involved in many oxidative stress diseases, cell signal transduction and cell proliferation process as well as diabetes complications. In recent years, some progress has been made in research of the activity and gene regulation of aldose reductase and the relation with many common diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Rhodanine
/
Signal Transduction
/
Aldehyde Reductase
/
Oxidative Stress
/
Therapeutic Uses
/
Diabetes Complications
/
Cell Proliferation
/
Drug Therapy
/
Enzyme Inhibitors
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2010
Type:
Article
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