Expression of VEGF-C and VEGF-D in gastric carcinoma and its relationship with lymph node metastases / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 335-340, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-814445
ABSTRACT
OBJECTIVE@#To explore the expression of vascular endothelial growth factor (VEGF) C and D in gastric cancer and its relationship with tumor angiogenesis and lymph node metastasis.@*METHODS@#Immunohistochemistry(SABC) and real-time PCR were used to detect the expression of VEGF-C, VEGF-D protein and mRNA in 32 gastric cancer tissues and 32 normal gastric tissues.@*RESULTS@#The positive expression rate of VEGF-C and VEGF-D in gastric cancer tissue was significantly higher than that of normal gastric tissues (P0.05).@*CONCLUSION@#The non-intake high expression of VEGF-C and VEGF-D in gastric cancer cells is closely related to lymph node metastasis. They serve as the important reference indicator to assess the prognosis in gastric cancer patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
RNA, Messenger
/
Reverse Transcriptase Polymerase Chain Reaction
/
Vascular Endothelial Growth Factor C
/
Vascular Endothelial Growth Factor D
/
Genetics
/
Lymphatic Metastasis
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2010
Type:
Article
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