Efficacy and safety of 3-dimensional conformal radiotherapy combined with temozolomide for glioma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1106-1110, 2011.
Article
in Zh
| WPRIM
| ID: wpr-814468
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the efficacy and safety of 3-dimensional conformal radiotherapy combined with temozolomide (TMZ) for gliomas.@*METHODS@#A total of 78 patients with pathologically confirmed glioma ( from September 2005 to March 2007) were postoperatively divided into 3 groups: a chemotherapy group (n=24), a radiotherapy group (n=25), and a comprehensive therapy group(n=29). The patients received temozolomide alone,3-dimensional conformal radiotherapy alone,3-dimensional conformal radiotherapy combined with temozolomide in the chemotherapy group,the radiotherapy group and the comprehensive therapy group respectively. The survival rate, progression-free survival, overall survival time and adverse reactions were observed.@*RESULTS@#The 3-year survival rate in the comprehensive therapy group was significantly higher than that in the other two groups. The 3-year survival rates were 20.83%, 20.00%, and 41.38% in the chemotherapy group, the radiotherapy group and the comprehensive therapy group respectively. The progression-free survival time was 17.68,17.94, and 23.29 months and the average overall survival time was 20.28, 21.54, and 25.75 months in the chemotherapy group, the radiotherapy group and the comprehensive therapy group, respectively.The adverse reactions were mild and tolerable.@*CONCLUSION@#Three-dimensional conformal radiotherapy combined with temozolomide is more effective for gliomas than the simple 3-dimensional conformal radiotherapy and the temozolomide chemotherapy alone.
Full text:
1
Index:
WPRIM
Main subject:
Postoperative Period
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Radiotherapy
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General Surgery
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Brain Neoplasms
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Survival Analysis
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Retrospective Studies
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Combined Modality Therapy
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Antineoplastic Agents, Alkylating
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Radiotherapy, Conformal
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Dacarbazine
Type of study:
Observational_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2011
Type:
Article