Correlation between expression of HIF-2α and OCT-4 and prognosis of NSCLC / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 854-858, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-814492
ABSTRACT
OBJECTIVE@#To investigate the expression and significance of hypoxia inducible factor-2α (HIF-2α) and transcription factor OCT-4 in non-small cell lung cancer (NSCLC), and evaluate their roles in the prognosis of NSCLC.@*METHODS@#Tissues from 51 cases of NSCLC were collected and immunohistochemistry (SP method) was used to detect the expression of HIF-2α and OCT-4 proteins. The correlation between the protein expression and the prognosis of NSCLC was analyzed.@*RESULTS@#The positive rates of HIF-2α and OCT-4 expression in the NSCLC were 52.9% and 72.5%, respectively. There was significant relation between the expression of HIF-2α and OCT-4 (r=0.514,P<0.01). High expression of them revealed poor prognosis for NSCLC patients characterized with a bad overall survival(P<0.05).@*CONCLUSION@#There is a negative corelation between the expression of HIF-2α and OCT-4 and the prognosis of NSCLC. Combined examination of HIF-2α and OCT-4 expression might be an important biomarker for NSCLC prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Biomarkers, Tumor
/
Carcinoma, Non-Small-Cell Lung
/
Diagnosis
/
Basic Helix-Loop-Helix Transcription Factors
/
Octamer Transcription Factor-3
/
Lung Neoplasms
/
Metabolism
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2011
Type:
Article
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