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Correlation between neutrophil cytosolic factor 1 gene C923T polymorphism and cerebral hemorrhage in the Han in Changsha / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 301-306, 2011.
Article in Chinese | WPRIM | ID: wpr-814576
ABSTRACT
OBJECTIVE@#To investigate the relation between C923T(Ala308Val)polymorphism in exon 10 of neutrophil cytosolic factor 1 (NCF1) gene and cerebral hemorrhage in the Han in Changsha and to evaluate the effect of C923T(Ala308Val) polymorphism on plasma lipid levels.@*METHODS@#Changsha Han C923T(Ala308Val)polymorphism in NCF1 gene was determined by PCR single strand conformation polymorphism analysis and DNA sequencing in 100 healthy controls, 110 patients with cerebral hemorrhage, and 10 cerebral hemorrhage pedigrees. The level of plasma lipid was measured by routine methods.@*RESULTS@#No significant difference was found in frequencies of genotypes and alleles of C923T(Ala308Val)polymorphism among the controls, cerebral hemorrhage patients and cerebral hemorrhage pedigrees. The serum level of TG in the CT genotype of cerebral hemorrhage patients and controls tended toward higher than that in CC genotype, but the trend did not reach significance (P>0.05).@*CONCLUSION@#There seems no correlation between C923T(Ala308Val)polymorphism and cerebral hemorrhage in Hans people in Hunan province.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Molecular Sequence Data / Base Sequence / Cerebral Hemorrhage / China / Reactive Oxygen Species / NADPH Oxidases / Asian People / Genetics / Metabolism Limits: Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Molecular Sequence Data / Base Sequence / Cerebral Hemorrhage / China / Reactive Oxygen Species / NADPH Oxidases / Asian People / Genetics / Metabolism Limits: Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2011 Type: Article