Comparison of endoscopic band ligation and propranolol for the primary prophylaxis of variceal bleeding in cirrhosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 513-516, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-814643
ABSTRACT
OBJECTIVE@#To compare endoscopic variceal ligation (EVL) with propranolol for prophylaxis of first variceal bleeding.@*METHODS@#We chose 168 patients with cirrhosis and esophageal varices in our hospital and allocated them to EVL and propranolol groups. Treatment effectiveness and safety in the 2 groups were observed.@*RESULTS@#he parameters of two groups were similar before therapy. Follow-up period was 8-36 months. Variceal bleeding occurred in 24 (28.6%) of the EVL group and in 20 (23.9%) of the propranolol group (P>0.05). Overall mortality and death related to bleeding were similar (21.4% vs 17.9%; 7.1% vs 6.0%, P>0.05). Adverse events related to EVL were 43 (3 of them life-threatening) compared to 16 in the propranolol group (51.19% vs 19.05%, P<0.05).@*CONCLUSION@#Propranolol may be the better choice in prophylaxis of variceal bleeding with similar effects and lower adverse events than with EVL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Propranolol
/
General Surgery
/
Therapeutics
/
Esophageal and Gastric Varices
/
Endoscopy, Gastrointestinal
/
Therapeutic Uses
/
Drug Therapy
/
Gastrointestinal Hemorrhage
/
Ligation
/
Liver Cirrhosis
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2012
Type:
Article
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