Developments in the study of CD40/ CD40L gene and its polymorphism in atherosclerosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 413-418, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-814656
ABSTRACT
CD40/CD40L is a pair of complementary transmembrane glycoproteins, expressed on immune cells, endothelial cells, smooth muscle cells, platelets and other cells involved in regulation of immunity, inflammation, coagulation and other pathophysiologic states. A large number of researches have demonstrated that, when atherosclerosis occurs, CD40L ligates CD40; subsequently CD40 is activated and stimulates downstream signaling pathways, including nuclear factor-kappaB, with consequent up-regulation of proinflammatory and proatherogenic genes. Thus it plays an important role in the occurrence, development and plaque-rupture of atherosclerosis. CD40/CD40L is a bridge between immunity, inflammation, and a hypercoagulable state, and may be an important target for prevention and treatment of cardiovascular disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Polymorphism, Genetic
/
NF-kappa B
/
CD40 Antigens
/
Thrombophilia
/
CD40 Ligand
/
Atherosclerosis
/
Genetics
/
Immunity
/
Inflammation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS