BRAF mutation and papillary thyroid cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 370-373, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-814666
ABSTRACT
OBJECTIVE@#To explore the association bewteen BRAF mutations and papillary thyroid cancer.@*METHODS@#BRAF gene mutations in 73 cases of papillary thyroid cancer and 16 cases of thyroid gland benign tumor were detected by PCR and sequencing technology.@*RESULTS@#We found 42 instances of BRAF mutations in 73 cases of thyroid cancer. However, no mutation was found in tissues from benign thyroid tumors. There were significant correlations between BRAF mutation and lymph node metastasis, and between BRAF mutation and the clinical stage of papillary thyroid cancer (P<0.05).@*CONCLUSION@#The mutation of BRAF is associated with the pathogenesis, lymph node metastasis, and clinical stage of papillary thyroid cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Neoplasms
/
Carcinoma, Papillary
/
Point Mutation
/
Proto-Oncogene Proteins B-raf
/
Genetics
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2012
Type:
Article
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