Study on the distribution of buprenorphione in the bodies of the rabbits / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the distribution of buprenorphione in the bodies of rabbits.@*METHODS@#Buprenorphione was administrated to rabbits orally or by intravenous injection (0.04 mg/kg buprenorphione). Two hours after administration, rabbits were killed and their blood, urine, liver, kidney, lung, stomach, brain, heart, stomach content and feces were collected. The concentrations of buprenorphione in these body fluids and tissues were determined by liquid chromatography-mass spectrometry (LC-MS).@*RESULTS@#The results show the distribution of buprenorphione in rabbit's body urine>stomach content>brain >heart >stomach>lung> kidney > liver > blood> feces.@*CONCLUSION@#The method developed can be used for the detection of buprenorphione in biological fluids and tissues in forensic practice. Urine is the preferred sample for screening for buprenorphione abuse.