Effect of Naoling decoction on the expression of microglia and IL-6 in hippocampal CA3 region of rats with synthetic Alzheimer's disease / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 113-119, 2013.
Article
in En
| WPRIM
| ID: wpr-814909
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To observe the effect of Naoling decoction on the learning and memory behaviors and the expression of microglia and IL-6 in hippocampal CA3 region of rats with Alzheimer's disease (AD), and to elucidate the potential mechanism.@*METHODS@#Thirty SD rats were randomly divided into 5 groups: a normal group, a sham-operation group, an AD group, a Naoling decoction group and a Naofukang group. The spatial learning and memory behaviors of the rats were investigated by water maze and Y-maze. The Alzheimer's disease model was established by injecting Aβ1-42 into the hippocamal of the rats. Expression of OX-42 (one of the microglia specific markers) and IL-6 in the CA3 region of hippocamal was measured by immunohistochemical stain.@*RESULTS@#Morris water maze experiment showed that the escape latency of hidden platform in the AD group was significantly delayed (P<0.05) and the average times of passing was decreased (P<0.05). Y-maze test showed that the times needed to the learn how to evade the electrical stimulation in the AD group was most than in other groups (P<0.05). Compared with the AD group, the Morris water maze test and Y-maze test of the Naoling decoction group were significantly different (P<0.05). The expression of OX-42 and IL-6 in the CA3 region of hippocamal in the Naoling decoction group was decreased (P<0.05).@*CONCLUSION@#Naoling decoction can improve learning and memory, and weaken the expression of OX-42 and IL-6 in hippocampal CA3 of AD rats, which may partly be the therapeutic mechanism of Naoling decoction for AD.
Full text:
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Index:
WPRIM
Main subject:
Pathology
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Drugs, Chinese Herbal
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Interleukin-6
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Rats, Sprague-Dawley
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Microglia
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Therapeutic Uses
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Disease Models, Animal
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Drug Therapy
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CA3 Region, Hippocampal
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Alzheimer Disease
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Journal of Central South University(Medical Sciences)
Year:
2013
Type:
Article