Effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 43-47, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-814925
ABSTRACT
OBJECTIVE@#To determine the effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats (SHRs).@*METHODS@#Thirty-two 10-week-old male SHRs were randomly assigned into 4 groups a left stellate ganglion block group (group LS), a right stellate ganglion block group (group RS), a captopril group (group D) and a control group (group C). The arterial systolic blood pressure (SBP) was measured by ALC-NIBP measuring system. After 10 weeks, we observed the left ventricular mass index (LVMI), myocardial pathologic changes, and detected the endothelin (ET-1) and endothelial nitric oxide synthase (eNOS) level in the left ventricle by radioimmunoassay and the collagen protein level in the left ventricle by immunohistochemical method.@*RESULTS@#Compared with group LS and group C, the LVMI in group RS was lowered most notably (P<0.05) and pathological changes were improved obviously. The expression of eNOS in group RS was significantly increased and ET-1 significantly decreased (P<0.05) compared with that in group C and group LS. The expression of type I collagen fibers in group RS was significantly lower and type III collagen fibers significantly higher (P<0.05) when compared with that in group C and LS.@*CONCLUSION@#Right stellate ganglion block can not only decrease the arterial pressure but also reverse the reconstruction of the left ventricle.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Rats, Inbred SHR
/
Autonomic Nerve Block
/
Stellate Ganglion
/
Therapeutics
/
Ventricular Remodeling
/
Hypertension
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2013
Type:
Article
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