Effect of pre-transplant donor specific antibody on antibody-mediated rejection and graft dysfunction / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To explore the effect of pre-transplant donor specific antibody (DSA) on antibody-mediated rejection (AMR) and function of transplanted kidney.
@*METHODS@#A total of 88 cases of renal transplant recipients were selected. Before surgery, DSA was examined by Luminex liquid phase chip in renal transplant recipients. The recipients were divided into a DSA positive group (n=20) and a DSA negative group (n=68). The follow-up time was 2 years. After the operation, the pathologic morphology of the transplanted kidney was evaluated and classified according to the Banff 2005 standard. The situation for the transplanted kidney was evaluated.
@*RESULTS@#The incidence of AMR in the DSA positive group and negative group was 20% and 1.5%, respectively, with significant difference between them (P0.05).
@*CONCLUSION@#The detection of DSA level before renal transplantation can predict the risk of AMR and the function of transplanted kidney. The MFI intercept point of the highest DSA (MFI>
7909.5) can be used to predict the risk of AMR.