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Relationship between serum cystatin-C levels and vibrating perception threshold in patients with 
Type 2 diabetes mellitus / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 58-64, 2016.
Article in Chinese | WPRIM | ID: wpr-815074
ABSTRACT
OBJECTIVE@#To explore the relationship between serum cystatin-C (Cys-c) levels and vibrating perception threshold (VPT) in patients with Type 2 diabetes mellitus (T2DM).
@*METHODS@#According to the symptoms, signs and results of lab examination, a total of 352 patients with T2DM were divided into a diabetic peripheral neuropathy group (DPN group, n=107) and a non-diabetic peripheral neuropathy group (NDPN group, n=245). Serum Cys-c levels were measured by radioimmunoassay method. The relationship between serum Cys-c levels and VPT, estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (ACR), glucose and blood pressure and other parameters were also analyzed by correlation and multiple regression analysis. All T2DM patients were divided into a high Cys-c levels group (n=89) and a low Cys-c levels group (n=263) according to the upper quartile of Cys-c, and the incidence of DPN and VPT levels in each group were compared. Risk factors of DPN in T2DM patients were analyzed by binary logistic regression analysis and receiver operating characteristic (ROC) curve was used to identify the optimal cutoff of serum Cys-c levels for predicting DPN in patients with T2DM.
@*RESULTS@#Serum Cys-c levels were significantly higher in the DPN group than that in the NDPN group [(1.04±0.43) vs (0.80±0.25) mg/L, P0.996 mg/L, the predicts have high risk of DPN in T2DM patients, which might be related to diabetic nephropathy, oxidative stress and inflammatory reaction induced by advanced age, hyperglycemia and hypertension.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Perception / Physiology / Vibration / Blood / Incidence / Prevalence / Risk Factors / Diabetes Mellitus, Type 2 / Diabetic Neuropathies / Cystatin C Type of study: Etiology study / Incidence study / Prevalence study / Prognostic study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Perception / Physiology / Vibration / Blood / Incidence / Prevalence / Risk Factors / Diabetes Mellitus, Type 2 / Diabetic Neuropathies / Cystatin C Type of study: Etiology study / Incidence study / Prevalence study / Prognostic study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2016 Type: Article