Expression of 5-lipoxygenase in human tissues and its association with disease / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 438-445, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-815155
ABSTRACT
5-Lipoxygenase, one of lipoxygenase isozymes, is a well-studied oxidative metabolism enzyme. It widely exists in various human tissues and cells, participates in the oxidative metabolism of endogenous and exogenous chemicals, and produces a variety of metabolites, all of which contribute to the occurrence of human diseases, such as inflammation, asthma, atherosclerosis, and tumor and so on. The expression of 5-lipoxygenase is at low level in normal human tissues while at high level in abnormal tissues. 5-Lipoxygenase is closely related to many kinds of diseases in human ovary, brain, cardiovascular system, lung, liver, pancreas and other tissues. The abnormal expression of 5-lipoxygenase tends to promote the development of the disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Arachidonate 5-Lipoxygenase
/
Atherosclerosis
/
Inflammation
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2015
Type:
Article
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