Correlation between children's dental decay and the contents of saliva CCL28 and secretory immunoglobulin A / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 102-106, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-815208
ABSTRACT
OBJECTIVE@#To explore the association of the dental decay of children with the contents of chemokine CCL28 and secretory immunoglobulin A (sIgA) in saliva.@*METHODS@#A total of 108 children in 2 kindergartens of Changsha, with age from 3 to 5 years old, were enrolled for this study. The saliva was collected from these children when they were in the examination of mouth. Th e children were divided into 3 groups A non-caries group [dynamical mean-field theory (DMFT)=0], a low caries group (DMFT=1-4) and a high caries group (DMFT ≥ 5). Th e contents of CCL28 and sIgA were measured by ELISA.@*RESULTS@#The contents of CCL28 and sIgA in saliva were (121.22 ± 32.63) pg/mL and (16.49 ± 8.02) μg/mL, respectively. A positive linear correlation was found between the CCL28 content and sIgA content in saliva (r=0.734). Th e CCL28 and sIgA contents in saliva were positively correlated with the degree of dental caries in children (P<0.05).@*CONCLUSION@#The dental decay of children leads to the secretion of chemokine CCL28, which promotes the secretion of sIgA in saliva.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Saliva
/
Immunoglobulin A, Secretory
/
Enzyme-Linked Immunosorbent Assay
/
Chemistry
/
Chemokines, CC
/
Dental Caries
Limits:
Child, preschool
/
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2015
Type:
Article
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