Biological characteristics of human olfactory mucosa mesenchymal stem cells / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 53-58, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-815214
ABSTRACT
OBJECTIVE@#To observe the biological characteristics of the human olfactory mucosa mesenchymal stem cells (hOM-MSCs).@*METHODS@#The hOM-MSCs were isolated, cultured and identified in vitro. Scanning electron microscope and transmission electron microscope were used to observe the ultrastructure of hOMMSCs. Th e cells were induced towards adipocyte, osteocyte, neural stem cells, neural-like-cells in vitro.@*RESULTS@#The hOM-MSCs were mainly in spindle shape, arranged with radial colony. The hOMMSCs expressed CD73 and CD90 but no CD34 and CD45. Th e short and thick microvilli processes were seen at the surface of hOM-MSCs by scanning electron microscope, and 2 different cellular morphology of hOM-MSCs were seen under transmission electron microscope. Moreover, the hOMMSCs could be differentiated into adipocyte, osteocyte, neural stem cells and neural cells.@*CONCLUSION@#The hOM-MSCs possess general biological characteristics of MSCs and display multiple differentiation functions. They can be served as ideal seed cells in tissue-engineering for injury repair.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Microscopy, Electron, Scanning
/
Cell Differentiation
/
Cells, Cultured
/
Olfactory Mucosa
/
Cell Biology
/
Microscopy, Electron, Transmission
/
Mesenchymal Stem Cells
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2015
Type:
Article
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