WEE1, histone and tumor / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 806-810, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-815267
ABSTRACT
WEE1 is an important factor for histone transcription, chromosome condensation and regulation of cell cycle progression. WEE1 kinase can phosphorylate Cdc2 and down-regulate Cdc2 kinase activity. It can regulate G2 to M phase transition and cell mitosis. It plays a key role in chromosome condensation delay and histone synthesis, suggesting the important functions of WEE1 in the occurrence and development in cancer. At present, a multiple WEE1 inhibitors have been discovered. A great progress has been made in combination of WEE1 inhibitors with DNA damage treatment (chemotherapy or radiotherapy), which makes WEE1 an important target in cancer treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
DNA Damage
/
Protein-Tyrosine Kinases
/
Nuclear Proteins
/
Histones
/
Cell Cycle
/
CDC2 Protein Kinase
/
Cell Cycle Proteins
/
Metabolism
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2015
Type:
Article
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