Prognostic value of statin for cancer patients:
A Meta-analysis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 770-781, 2015.
Article
in English
| WPRIM
| ID: wpr-815272
ABSTRACT
OBJECTIVE@#To systematically evaluate the effect of statins on prognosis for patients with cancers.
@*METHODS@#Literature on PubMed, EMbase and Cochrane library was screened from the establishment of databases to March, 2015 to find relevant studies. Random-effects models were used to calculate the pooled hazard ratios (HR) and 95% confidence interval (CI) for the association between statin use and all-cause mortality and cancer-specific mortality.
@*RESULTS@#A total of 25 studies covered 523 193 patients were identified and included in this Meta-analysis. The pooled effect showed that statin application was associated with a reduction in all-cause mortality in cancer patients (HR, 0.82; 95% CI 0.76 to 0.89). A significantly decreased mortality in prostate cancer was revealed in subgroup by cancer sites (HR, 0.66; 95% CI 0.52 to 0.83). In addition, sensitivity analysis demonstrated a weakened association between statin application and all-cause mortality after excluding the studies with shorter follow-up duration (HR, 0.91; 95% CI 0.75 to 1.10).
@*CONCLUSION@#A beneficial effect of statin on all-cause mortality and cancer-specific mortality is presented in patients with cancer. However, further studies are needed to confirm the long term effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Prostatic Neoplasms
/
Mortality
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Therapeutic Uses
/
Drug Therapy
/
Neoplasms
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2015
Type:
Article
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