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Analysis of influential factors for prostate biopsy and establishment of logistic regression model for 
prostate cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 651-656, 2015.
Article in Chinese | WPRIM | ID: wpr-815292
ABSTRACT
OBJECTIVE@#To establish logistic regression model for prostate cancer and provide basis for prostate biopsy.
@*METHODS@#A total of 117 cases of prostate biopsy were retrospectively analyzed in chronological sequence. All cases were assigned into a model group (n=78) and a validation group (n=39). Logistic regression model was established and its value was estimated by receiver operating characteristic (ROC) curve. 
@*RESULTS@#Digital rectal examination(DRE), transrectal ultrasound(TRUS), MRI, prostate-specific antigen density (PSAD), and free PSA/total PSA (fPSA/tPSA) were the influential factors for prostate biopsy (P<0.01). The established logistic regression model for prostate cancer by regression coefficient was logit P=-2.362+2.561×DRE+1.747×TRUS+2.901×MRI+1.126×PSAD-
2.569×fPSA/tPSA and area under curve was 0.907. When the cutoff aimed at 0.12, the sensitivity and specificity were 81.80% and 89.30%, respectively.
@*CONCLUSION@#Logistic regression model for prostate cancer can provide sufficient basis for prostate biopsy. Prostate biopsy should be performed when P value is more than 0.12.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prostatic Neoplasms / Urologic Surgical Procedures / Biopsy / Blood / Logistic Models / Retrospective Studies / ROC Curve / Sensitivity and Specificity / Prostate-Specific Antigen Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans / Male Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prostatic Neoplasms / Urologic Surgical Procedures / Biopsy / Blood / Logistic Models / Retrospective Studies / ROC Curve / Sensitivity and Specificity / Prostate-Specific Antigen Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans / Male Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2015 Type: Article