1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and
cognitive dysfunction / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 639-645, 2015.
Article
in Zh
| WPRIM
| ID: wpr-815294
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To detect metabolic changes of bilateral frontal lobe in patients with multiple system atrophy (MSA) and cognitive dysfunction by 1H-proton magnetic resonance spectroscopy (1H-MRS).
@*METHODS@#N-acetylaspartate (NAA)/creatine(Cr), choline (Cho)/Cr, myoinositol (mI)/Cr in three sides of frontal lobe were detected by 1H-MRS in 48 healthy controls, 23 patients with MSA and cognitive dysfunction and 19 patients with MSA but without cognitive dysfunction.
@*RESULTS@#NAA/Cr of bilateral frontal lobes in patients with MSA and cognitive dysfunction was significantly decreased compared with MSA patients without cognitive dysfunction and healthy controls (P<0.05). mI/Cr of right frontal lobes was significantly increased in patients with MSA and cognitive dysfunction compared with healthy controls (P<0.05). There was a negative correlation between NAA/Cr of bilateral frontal lobes and duration while a positive correlation between NAA/Cr of bilateral frontal lobes and MoCA score in patients with MSA and cognitive dysfunction.
@*CONCLUSION@#There is a decrease in NAA/Cr and an increase in mI/Cr in frontal lobes in patients with MSA and cognitive dysfunction, which may be associated with cognitive dysfunction in MSA patients.
Full text:
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Index:
WPRIM
Main subject:
Choline
/
Aspartic Acid
/
Cognition Disorders
/
Multiple System Atrophy
/
Creatine
/
Proton Magnetic Resonance Spectroscopy
/
Frontal Lobe
/
Inositol
/
Metabolism
Limits:
Humans
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2015
Type:
Article