Screening of the anti-tumor active fraction from Ipomoea batatas Lam. (cv.simon) leaves / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#Three fractions (SM, SM-A, SM-B) were prepared from different polarity parts of Ipomoea batatas Lam. (cv.simon) leaves and the anti-tumor potency as well as the dose-response relations were evaluated.@*METHODS@#The anti-tumor activities of fraction SM, SM-A or SM-B were screened by MTS in human hepatic cancer Hep3B cells, lung cancer A549 cells or gastric carcinoma MGC803 cells, respectively.@*RESULTS@#The three fractions all showed anti-tumor activities in three cancer cells with different sensitivity. Among them, SM-B was the most potent fraction with IC50 values at 15.17 mg/L, 72.64 mg/L or 165.47 mg/L in MGC803 cells, A549 cells or Hep3B cells, respectively (P<0.05).@*CONCLUSION@#Th e extraction of Brazil sweet potato leaves displayed anti-tumor activity and SM-B was the most potent fraction.