Impact of sitagliptin on aspirin resistance in patients with Type 2 diabetes mellitus / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1186-1191, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-815356
ABSTRACT
OBJECTIVE@#To explore the impact of sitagliptin on aspirin resistance (AR) in patients with Type 2 diabetes mellitus (T2DM).
@*METHODS@#A total of 68 cases of AR were chosen from 136 cases of T2DM patients. The clinical data, including blood samples, fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), and high sensitive C reactive protein (hs-CRP) were collected. Aenosine diphosphate (ADP) and arachidonic acid (AA) -induced platelet aggregation rate (PAG) were detected in 1, 3, 6 and 12 months after the treatment to evaluate the impact of sitagliptin on AR.
@*RESULTS@#After 6 months of hypoglycemic treatment, FPG and HbAlc in two groups were at the normal level. The hypoglycemic effect was not obviously different (P>0.05), but the hsCRP and ADP or AA-induced PAG were decreased in the sitagliptin group with statistical significance when compared with the metformin group (P<0.05).
@*CONCLUSION@#Sitagliptin can significantly improve the oxidative stress inflammatory state in T2DM patients and AR, which is independent on blood glucose control.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Blood Glucose
/
C-Reactive Protein
/
Drug Resistance
/
Glycated Hemoglobin
/
Aspirin
/
Oxidative Stress
/
Diabetes Mellitus, Type 2
/
Drug Therapy
/
Sitagliptin Phosphate
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2015
Type:
Article
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