Carotid intima-media thickness and estimated glomerular filtration rate in hypertensive patients / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 465-470, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-815409
ABSTRACT
OBJECTIVE@#To determine the association between carotid atherosclerosis and renal function in hypertensive patients.@*METHODS@#A total of 2 809 hypertensive patients aged (56.59±10.79) years were enrolled. Carotid intima-media thickness (cIMT) was derived via B-mode ultrasonography and chronic kidney disease (CKD) was evaluated by the estimated glomerular filtration rate (eGFR) with Cockcroft- Gault method. The patients were divided into 3 groups a normal group, a thick group, and a plaque group according to the results of carotid ultrasonography.@*RESULTS@#The eGFR of the normal group was (111.09±25.61) mL/(min.1.73m(2)), that of the thick group and the plaque group was (94.45±27.14) mL/(min.1.73m(2)) and (85.98±26.92) mL/ (min.1.73m(2)). Binary logistic analysis showed that age (OR=3.590), smoking status (OR=1.543), systolic blood pressure (OR=1.018), diastolic blood pressure (OR=0.977), fasting plasma glucose (OR=1.132), triglyceride (OR=0.873) and eGFR (OR=0.986) were significantly correlated with cIMT. Subgroup analyses on different genders showed that eGFR was a significant independent risk factor in men (OR=0.991) but not in women.@*CONCLUSION@#The thicker the cIMT, the lower the eGFR in hypertensive patients. With the development of cIMT, eGFR gradually decreases and contributes to the occurrence and development of early-stage atherosclerosis in hypertensive patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood Pressure
/
Diagnostic Imaging
/
Carotid Arteries
/
Carotid Artery Diseases
/
Smoking
/
Risk Factors
/
Renal Insufficiency, Chronic
/
Atherosclerosis
/
Carotid Intima-Media Thickness
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article
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