Effect of alendronate amount on the static mechanical properties of bone cement / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 178-184, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-815443
ABSTRACT
OBJECTIVE@#To determine the effect of alendronate amount on the static mechanical properties of bone cement before elution and 4 weeks after elution, and determine suitable amount of alendronate in cement from the perspective of biomechanics.@*METHODS@#Samples of compression strength and bending strength (modulus) were prepared with bone cement adding 0, 10, 50, 100, 500 and 1000 mg alendronate in 50 g Cemex®XL bone cement powders respectively (named as G0-G5 groups). The compression strength, bending strength, and bending modulus of bone cement were examinated by INSTRON 8032 tester before the elution and 4 weeks after the elution. Some broken samples of 4-point bending test were examinated by scanning electronic microscopy (SEM), and some other samples of bending strength (modulus) tests by micro-CT.@*RESULTS@#No significant difference was found in the compression strength before the elution,4 weeks after elution in the 6 groups, and before and after the elution in the respective groups (P>0.05). Compared with G0 group, G1-G4 groups had no obvious difference in the bending strength before the elution and 4 weeks after the elution (P>0.05), while G5 group had difference (P0.05). Taken G0 group as the control group, G1-G4 groups had no visible effects on the bending modulus 4 weeks after the elution (P>0.05), while G5 group decreased it significantly (P0.05), while bending modulus before and after the elution in the respective groups displayed a marked difference (P<0.05).@*CONCLUSION@#Less than 500 mg alendronate added in Cemex?XL 50 g bone cement powder does not decrease the compressive strength, flexural strength and flexural modulus before the elution and 4 weeks after the elution.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Powders
/
Bone Cements
/
Materials Testing
/
Microscopy, Electron, Scanning
/
Chemistry
/
Alendronate
/
Compressive Strength
/
Elastic Modulus
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article
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