Changes of plasminogen activator inhibitor-1 and D-dimer during continuous blood purification and related factors / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 67-72, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-815461
ABSTRACT
OBJECTIVE@#To observe the changes of plasminogen activator inhibitor-1 and D-dimer during continuous blood purification (CBP) and related factors.@*METHODS@#Sixteen patients who were diagnosed with multiple organ dysfunction syndrome (MODS) were randomly divided into 2 groups 8 patients received standard continuous blood purification with heparin anticoagulation, and the other 8 received CBP without anticoagulation. Ten normal blood samples were collected from healthy volunteers as controls. All patients underwent CBP for 8 h. Blood was taken from those patients at 0, 15, 60, 120 and 480 min during the CBP. Plasma plasminogen activator inhibitor-1, D-dimer and serum TNF-α and IL-1β were measured by ELISA.@*RESULTS@#Plasma levels of PAI-1 and D-dimer were increased significantly compared with those in the control group (P<0.05). Plasma level of PAI-1 was reduced (P<0.05) and D-dimer was increased (P<0.05) after the CBP. The level of plasma PAI-1 in the heparin group was significant reduced compared with the group of CBP without anticoagulation (P<0.05). There was negative correlation between the level of PAI-1 and the dosage of heparin used during a CBP session in the heparin group (r=-0.746, P<0.001).@*CONCLUSION@#The level of PAI-1 and D-dimer is higher in patients with MODS than that in the normal controls. After the CBP treatment, there is significant decrease in PAI-1 and increase in D-dimer in both groups. Heparin used during CBP can reduce PAI-1 which intensifies its function of anticoagulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Fibrin Fibrinogen Degradation Products
/
Heparin
/
Renal Dialysis
/
Tumor Necrosis Factor-alpha
/
Plasminogen Activator Inhibitor 1
/
Therapeutic Uses
/
Interleukin-1beta
/
Anticoagulants
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article
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