Application of serum thymidine kinase 1 of 26 055 cases in health screening for early detection of premalignant/early malignant tumors / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1029-1034, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-815488
ABSTRACT
OBJECTIVE@#To determine the application of serum thymidine kinase 1 (STK1) in general health screening for early detection of premalignant/early malignant tumors.@*METHODS@#A cross sectional study was carried out in 26 055 health screenings from 8 centers of Changsha in 2011. The concentration of STK1 was determined by a sensitive chemiluminescent dot blot ECL assay.@*RESULTS@#In the elevated STK1 group 60.35% showed diseases with a higher risk of premalignant/ early cancerous progression. The positive rate of elevated STK1 (>2.0 pmol/L) was 2.61%. There was a significantly higher rate with moderate/severe type of hyperplasia of breasts and prostate with elevated STK1 than people with normal STK1 values.@*CONCLUSION@#STK1 may be a reliable marker for risk assessment of premalignant/early malignant tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Precancerous Conditions
/
Prostate
/
Thymidine Kinase
/
Blood
/
Breast
/
Biomarkers, Tumor
/
Cross-Sectional Studies
/
Diagnosis
/
Early Detection of Cancer
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Risk factors
/
Screening study
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS