Expression of the HIF-2α in epithelial ovarian cancer and clinical significance / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the expression of hypoxia inducible factor 2α (HIF-2α) in every clinical stage and the pathological grade of epithelial ovarian cancer, and to discuss the role of HIF-2α in carcinogenesis, progression and outcomes of epithelial ovarian tumors.@*METHODS@#Protein expression of HIF-2α in epithelial ovarian tissue from 77 randomly selected specimens was detected by SP immunohistochemistry staining. The relation between the expression of HIF-2α and prognosis of 40 patients with epithelial ovarian cancer was analyzed by Cox regression model.@*RESULTS@#There was positive relation between the positivity rates of HIF-2α and malignant grade, FIGO stage, histological grade and invasive metastasis. The live time of the patients with HIF-2α positive expression was shorter than those with negative expression.@*CONCLUSION@#HIF-2α may play an important role in the genesis, development, invasion and metastasis of ovarian cancer and it may possess the vital clinical significance for prognosis evaluation.