Relation between serum myostatin with BMI and PaO₂/PaCO₂ in patients with chronic obstructive pulmonary disease / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 807-810, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-815525
ABSTRACT
OBJECTIVE@#To determine the relation between serum myostatin with body mass index (BMI) and PaO₂/PaCO₂ in men with chronic obstructive pulmonary disease (COPD).@*METHODS@#A cohort of outpatients with stable COPD was evaluated. We evaluated the myostatin, PaO₂/PaCO₂ and BMI, and the patients were stratified by BMI. The plasma level of myostatin and PaO₂/PaCO₂ was measured by high sensitivity ELISA or blood gas analysis.@*RESULTS@#PaCO₂ and myostatin increased significantly compared with those in the control group (P<0.05), but PaO₂ decreased significantly. There was positive correlation between myostatin and PaCO₂ (P<0.05), and negative correlation between myostatin and BMI/FEV1/pred value/PaO₂ (P<0.05).@*CONCLUSION@#Patients with higher myostatin levels had a lower BMI, lower PaO₂ and higher PaCO₂, with poor pathogenetic condition and prognosis. Myostatin may be a potential treatment target in patients with chronic obstructive pulmonary disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Blood
/
Blood Gas Analysis
/
Body Mass Index
/
Pulmonary Disease, Chronic Obstructive
/
Myostatin
/
Monitoring, Physiologic
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS