Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat
Yonsei Medical Journal
;
: 453-462, 1998.
Article
in English
| WPRIM
| ID: wpr-81584
ABSTRACT
The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the polyol pathway is a probable mechanism for these two abnormalities. Investigations have suffered from the lack of an exact animal model simulating the human condition. Examination of the retina in the spontaneously diabetic SHR/NMcc-cp rat demonstrated degeneration and loss of intramural pericytes, a progressive increase in basement membrane thickness, and microinfarctions with an area of non-perfusion. Therefore, this model may be used to clarify the biochemical mechanisms linking the metabolic abnormalities of diabetes and retinopathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Inbred SHR
/
Rats, Inbred Strains
/
Retina
/
Retinal Degeneration
/
Diabetic Retinopathy
/
Disease Models, Animal
/
Animals
Limits:
Animals
Language:
English
Journal:
Yonsei Medical Journal
Year:
1998
Type:
Article
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