Alterations of the circadian rhythm in Parkinson's disease / 中国实用内科杂志

ABSTRACT

Many physiological activities including endocrine, metabolism and immunity are regulated by circadian rhythm. Abnormal circadian rhythms are associated with a variety of diseases, including tumer, obesity, diabetes and mood disorders, as well as neurodegenerative diseases. Parkinson's disease is the second most common neurodegenerative disease, second only to Alzheimer's disease. The cardinal features of Parkinson's disease include rest tremor, bradykinesia, rigidity, and gait impairment, which are also accompanied by many non-motor symptoms. Circadian dysfunction is one of the most common non-motor symptoms of Parkinson's disease, which may occur before the onset of motor symptoms or last throughout the course of the disease, causing significant negative effects on the quality of life of patients and caregivers. In this article we review the clinical manifestations, biological markers and current treatment strategies of circadian dysfunction in Parkinson's disease.