Clinical evaluation of protein-amino acid metabolic disorders / 中国实用内科杂志

ABSTRACT

Proteins are macro-molecules crucial for cell life, which are made up of amino acids(AAs). The biochemical consequence of hyper-catabolism is protein disarrangement, clinically evident with signs such as sarcopenia, hypalbuminemia,anaemia, infection, and altered fluid compartmentation, etc. Therefore, identification and treatment of proteins' metabolic impairment with appropriate measurements and therapy is a clinical strategy that can improve the prognosis of patients with acute/chronic hypercatabolic inflammatory disease. Here, we describe the role metabolism of protein and AAs in hypercatabolic syndrome, illustrating the clinical impact of protein disarrangement and also illustrate simple, cheap, repeatable, and worldwide available measurements to identify these conditions in order to provide scientific evidence for HPD nutritional treatment.