Study of blastocyst transfer in increasing the risk of blighted ovum / 中国实用妇科与产科杂志

ABSTRACT

OBJECTIVE: To explore the incidence and embryo factors of blighted ovum in twin pregnancies achieved by assisted reproductive technology(ART)under controlling for maternal factors by vanishing twin.METHODS: A retrospective analysis was conducted in 610 cases of twin pregnancies achieved by IVF/ICSI twin transfer,who were treated in Nanfang Hospital of Southern Medical University from Jan. 2012 to Jan. 2018,including 474 twin live-birth pregnancies and 136 blighted ovum with singleton live-birth pregnancies. The clinical data of the 2 groups were analyzed for comparisons of the maternal factors,including maternal age,paternal age,BMI,AFC,bFSH/bLH and so on,and embryonic factors,like methods of fertilization,embryo types,proportion of high-quality embryos on DAY3 and so on.RESULTS: There was statistical difference in the serum β-hCG and rate of blastocyst transfer betweeen the two groups(P0.05). Also methods of fertilization,proportion of high-quality embryos on DAY3 and FET cycles were not statistically different between 2 groups.Multifactor Logistic regression analysis showed that blastocyst transfer was the risk factor of blighted ovum(OR=19.386,P<0.05),and β-hCG level was the protective factor(OR=0.290,P<0.05).CONCLUSION: Studying blighted ovum with singleton live birth pregnancies,a kind of vanishing twin syndrome,can control blighted ovum-related maternal factors. Blastocyst transfer may increase the risk of blighted ovum,and low β-hCG level is the predictor of the incidence of blighted ovum.