Effects of probiotics on liver function, glucose and lipids metabolism, fecal flora in children with nonalcoholic fatty liver disease / 中国学校卫生

ABSTRACT

Objective@#To investigate the effects of probiotics on liver function, glucose and lipids metabolism, fecal flora in children with nonalcoholic fatty liver disease (NAFLD), and to further provide a reference for analyzing the feasibility and effectiveness of the treatment of NAFLD.@*Methods@#A total of 120 children with NAFLD during June 2017 to December 2018 in The Fenghua People’s Hospital of Ningbo were randomly divided into observation group and control group, 60 cases in each group. The control group received diet and exercise therapy, while the observation group received orally probiotics based on the control group, and the intervention lasted for 3 months. The indexes of liver function, glucose and lipids metabolism, the effective rate and imbalance of fecal flora in two groups were compared before and after intervention.@*Results@#Before treatment, there were no significant differences in alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamine transferase (GGT), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), insulin resistance index (HOMA-IR) and imbalance of fecal flora in two groups were compared before and after intervention (P>0.05). For the comparisons after treatment in two groups, including the ALT (30.49±11.03 vs 24.76±9.54)U/L, AST (37.66±12.91 vs 32.05±12.38)U/L, GGT (20.81±8.32 vs 16.07±6.69)U/L, TC (3.90±0.93 vs 3.41±0.87)mmol/L, TG (1.50±0.42 vs 1.14±0.40)mmol/L, HOMA-IR (1.46±0.53 vs 1.22±0.45), these parameters in observation group was higher than those in control group, and the differences were statistically significant(t=3.04，2.43，3.44，2.98，4.81，2.67，P<0.05); After treatment, the imbalance of fecal flora in the observation group was better than that in the control group, and the difference was statistically significant (Hc=8.34, P=0.02).@*Conclusion@#Probiotics are beneficial for liver function, glucose and lipid metabolism, fecal flora for NAFLD patients in children, so as to enhance the therapeutic effect of NAFLD.