Platelet Indices Are Associated with Disease Activity Scores and the Severity of Sacroiliitis on Magnetic Resonance Imaging in Axial Spondyloarthritis Patients
Journal of Rheumatic Diseases
;
: 288-296, 2016.
Article
in English
| WPRIM
| ID: wpr-81686
ABSTRACT
OBJECTIVE:
To investigate the associations among platelet indices, disease activity scores, and inflammatory markers in axial spondyloarthritis, and to determine the relation between platelet indices and inflammation measured on magnetic resonance imaging (MRI).METHODS:
The study included 161 patients who fulfilled Assessment of Spondyloarthritis International Society criteria. Platelet indices such as mean platelet volume (MPV), plateletcrit (PCT), platelet large cell ratio (PLCR), and platelet distribution width (PDW) were measured. Ninety patients underwent sacroiliac (SI) MRI at baseline. Bone marrow edema (BME) and erosion on MRI were scored using the SPondyloArthritis Research Consortium of Canada (SPARCC) method. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score (ASDAS) and spinal radiologic progression were also assessed. The associations among platelet indices and disease activity scores and inflammatory markers were evaluated.RESULTS:
Of the 161 patients, 130 (81%) were male. MPV, PLCR, and PDW were negatively associated with ASDAS and inflammatory marker expression, whereas PCT was positively associated with these parameters. MPV, PLCR, and PDW were negatively associated with BME and erosion scores on SI MRI. However, platelet indices were not associated with the BASDAI and BASFI. The mean erythrocyte sedimentation rate, C-reactive protein, and BME and erosion scores were significantly higher in patients with low MPV. Changes in MPV, PCT, and PDW at baseline and after one year were associated with changes in ASDAS and inflammatory marker expression.CONCLUSION:
Platelet indices are associated with ASDAS, inflammatory marker levels, and severity of BME and erosion measured on MRI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spondylitis, Ankylosing
/
Baths
/
Blood Platelets
/
Blood Sedimentation
/
Bone Marrow
/
Canada
/
C-Reactive Protein
/
Magnetic Resonance Imaging
/
Edema
/
Sacroiliitis
Type of study:
Prognostic study
Limits:
Humans
/
Male
Country/Region as subject:
North America
Language:
English
Journal:
Journal of Rheumatic Diseases
Year:
2016
Type:
Article
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