Efficacy of Zinc Preparation for Radiation-induced Oral Mucositis in Head and Neck Cancers ：A Meta-analysis / 中国药房

ABSTRACT

OBJECTIVE： To systematically evaluate therapeutic efficacy of Zinc preparation for radiation-induced oral mucositis （ROM） in head and neck cancers， and to provide evidence-based reference for clinical treatment. METHODS： Retrieved from PubMed， Medline， Embase， the Cochrane library， CJFD，VIP and Wanfang database， RCTs about additional use of Zinc preparation （trial group） in adjunctive treatment of ROM in head and neck cancers base on routine treatment or blank control （control group） were collected during database establishment to Dec. 2018. After data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0， Meta-analysis was carried out for the incidence of ROM within 2 weeks after medication， total incidence of ROM and the incidence of serve ROM by using Rev Man 5.3 statistical software. RESULTS： A total of 8 RCTs were included， involving 550 patients. Results of Meta-analysis showed that there was no statistical significance in the incidence of ROM within 2 weeks [OR＝0.55， 95％CI（0.26，1.17）， P＝0.12]， total incidence of ROM [OR＝0.59， 95％CI（0.08，4.39）， P＝0.60] or the incidence of serve ROM [OR＝0.58， 95％CI（0.23，1.47）， P＝0.25] between 2 group. CONCLUSIONS： Based on routine therapy or blank control， additional use of Zinc preparation can not reduce the incidence and control the development of ROM in head and neck cancers.